Jizz

Isaac Clarke knows how to multitask.

DirtyGaming

Isaac is cake sexual

trollingspree

Isaac Yentes

lovegaymale

Isaac Way

lovegaymale

Isaac and Blue Baby are going to be hell... first time max fire rate.

bindingofisaac

Isaac Haldeman, having his butt drawn. (xpost /r/fashpics)

gaygentlemanboners

[Spoiler] MFW I've been playing Isaac for the last 6 hours straight

bindingofisaac

Isaac's Heart + Too many followers to stay on screen = invincible Isaac

bindingofisaac

Eve - Whore of Babylon [The Binding of Isaac]

rule34, TBoIRule34

(NSFW) So I woke up to this adorable Isaac themed card.

bindingofisaac

My all time favorite Isaac fan art by Pigeon666 [NSFW]

bindingofisaac

Isaac Newton / Gottfried Leibniz

rule34roots

[NSFW] 15 mins into isaac and chill and he gives you this look

NLSSCircleJerk, mistyfront

LiberLibelula allowed me to make a canvas print of her awesome Isaac art! 3ft x 2ft.

bindingofisaac

Isaac and Eve

TBoIRule34

Isaac Asimov tells a joke involving profanity

RedditDayOf, mistyfront

Yo Woolie, you wanted hyper-realistic Isaac?

TwoBestFriendsPlay

Isaac/Steven

TBoIRule34

Isaac being a ho

TBoIRule34

Definitely the first Binding of Isaac porn I've seen. Feat. Lilith (venusflowerart) [The Binding of Isaac]

rule34, DirtyGaming, rule34feet

Eve’s secret ending [The Binding of isaac](Tarakanovich)

rule34, WesternHentai, FunForFree, u_xXFallsXx, gapinghentai, TBoIRule34

Maria, João and Isaac, Southern Portugal Gypsies by Pierre Gonnord, 2014 [2252x3000]

HumanPorn, NoSillySuffix

Isaac and Ranjann Dominated [M/M] by kaynine

Footpaws

Isaac deserves better...

TBoIRule34

Isaac cosplays as Guppy

TBoIRule34

Isaac and The Adversary (◕‿◕)

TBoIRule34

Isaac blowjobbins'

TBoIRule34

Isaac being the hoe he's always been :p

TBoIRule34

Isaac™ Brand Changing Table

ImGoingToHellForThis

I made a cursed Isaac in Soul Calibur

bindingofisaac

Isaac's wardrobe malfunction

TheOrville

Edwina Carla Isaac

smalltitsbigass

Isaac

latinomen

Isaac Churchill

malemodels

Isaac Churchill

malemodels

The Isaac of Isaac Comic

u_anintendofan1

Elisabeth Giolito by Isaac Zoller (AIC)

NSFWfashion, u_dogtor95, u_stilllostwithyou

Oh, how innocent of a time this was!

u_Isaac_Ludwig666

Isaac Newton

funny

Isaac

latinomen

Isaac x Big Fan because why not, I guess...

TBoIRule34

Isaac makes a friend

TBoIRule34

Isaac draws himself and his friends but oh boy

TBoIRule34

first isaac work

TBoIRule34

Isaac [MF] (Chocobaby)

furryfemdom

Hush made cookies for everyone because Isaac's mom won't

TBoIRule34