Jizz

Isaac Clarke knows how to multitask.

DirtyGaming

Just me and my little friend, waiting out Isaac.

ladybonersgw

Isaac is cake sexual

trollingspree

Isaac Yentes

lovegaymale

Isaac Way

lovegaymale

Grey Delisle and Jason Isaacs roles.

TheLastAirbender

Isaac and Blue Baby are going to be hell... first time max fire rate.

bindingofisaac

Isaac Haldeman, having his butt drawn. (xpost /r/fashpics)

gaygentlemanboners

[Fan Art?] King Isaac, Hobby horse, and angel wiener (semi-NSFW)

bindingofisaac

[Spoiler] MFW I've been playing Isaac for the last 6 hours straight

bindingofisaac

Isaac's Heart + Too many followers to stay on screen = invincible Isaac

bindingofisaac

Eve - Whore of Babylon [The Binding of Isaac]

rule34, TBoIRule34

(NSFW) So I woke up to this adorable Isaac themed card.

bindingofisaac

My all time favorite Isaac fan art by Pigeon666 [NSFW]

bindingofisaac

Hold still Isaac.

bindingofisaac

I found this on the Binding of Isaac rule 34 sub.

MonsterGirl

Isaac Newton / Gottfried Leibniz

rule34roots

[NSFW] 15 mins into isaac and chill and he gives you this look

NLSSCircleJerk, mistyfront

Afterbirth got me wanting to draw Isaac fan art again

bindingofisaac

What a wonderful night to have a curse... [The Binding Of Isaac]

futanari

LiberLibelula allowed me to make a canvas print of her awesome Isaac art! 3ft x 2ft.

bindingofisaac

Isaac and Eve

TBoIRule34

Isaac Asimov tells a joke involving profanity

RedditDayOf, mistyfront

Yo Woolie, you wanted hyper-realistic Isaac?

TwoBestFriendsPlay

We've gone full Deli. There is no more Isaac. There is only Deli now.

TBoIRule34

Isaac/Steven

TBoIRule34

Isaac being a ho

TBoIRule34

Definitely the first Binding of Isaac porn I've seen. Feat. Lilith (venusflowerart) [The Binding of Isaac]

rule34, DirtyGaming, rule34feet

Eve’s secret ending [The Binding of isaac](Tarakanovich)

rule34, WesternHentai, FunForFree, u_xXFallsXx, gapinghentai, TBoIRule34

Maria, João and Isaac, Southern Portugal Gypsies by Pierre Gonnord, 2014 [2252x3000]

HumanPorn, NoSillySuffix

Isaac and Ranjann Dominated [M/M] by kaynine

Footpaws

Isaac deserves better...

TBoIRule34

Isaac cosplays as Guppy

TBoIRule34

Isaac and The Adversary (◕‿◕)

TBoIRule34

Isaac blowjobbins'

TBoIRule34

Isaac being the hoe he's always been :p

TBoIRule34

Nicole Isaacs has HUGE ones

BustyPetite, 2busty2hide

Isaac™ Brand Changing Table

ImGoingToHellForThis

I made a cursed Isaac in Soul Calibur

bindingofisaac

Isaac's wardrobe malfunction

TheOrville

Rafael Isaac Gomez

malemodelsNSFW

Edwina Carla Isaac

smalltitsbigass

Isaac

latinomen

Isaac Churchill

malemodels

Isaac Churchill

malemodels

The Isaac of Isaac Comic

u_anintendofan1

Elisabeth Giolito by Isaac Zoller (AIC)

NSFWfashion, u_dogtor95, u_stilllostwithyou

Paused binding of Isaac to be here (OC)

RealAhegao

Gamer boi (OC) I pretty much only play binding of Isaac it's so good

bois

Oh, how innocent of a time this was!

u_Isaac_Ludwig666

Isaac Newton

funny

Isaac

latinomen

The Lewding of Isaac: The Fly Update

TBoIRule34

Isaac x Big Fan because why not, I guess...

TBoIRule34

The Character Select screen if Isaac were a Coomer

TBoIRule34

Isaac makes a friend

TBoIRule34

Isaac draws himself and his friends but oh boy

TBoIRule34

first isaac work

TBoIRule34

Isaac [MF] (Chocobaby)

furryfemdom

Hush made cookies for everyone because Isaac's mom won't

TBoIRule34